The Peace Center in downtown Greenville is set to open Coach Music Factory, a new standing-room-only venue for live music with a capacity of 1,100. The venue, housed in a historic building originally built in 1857, features a modern industrial design with original brick walls and hardwood floors, as well as three full-service bars and an outdoor patio balcony. The third floor has been repurposed into a private event space. The venue's opening night will feature a sold-out performance by G. Love & Special Sauce, followed by The Lone Bellow and The Infamous Stringdusters.

Coach Music Factory, a new live music space at the Peace Center, announces its first acts for 2026. The first announced shows are G. Love & Special Sauce (Feb. 7, 2026), The Lone Bellow (March 27, 2026) and The Infamous Stringdusters (April 26, 2026). Tickets for all three performances go on sale at 10 a.m. Nov. 21 at peacecenter.org.

TreesUpstate, a local nonprofit, will host its annual Turkey Day 8K and 5K race in downtown Greenville on Thanksgiving morning. The event, sponsored by more than 40 corporate sponsors, is expected to draw over 7,000 runners and is the largest race in the Upstate and the third largest in South Carolina. Participants are encouraged to wear costumes and can pick up a free energy-saving tree through TreesUpstate's Energy Saving Trees Program, sponsored by Duke Energy. The event will cause temporary road closures between 8-10 a.m. on Thanksgiving Day.

Prisma Health has launched the Sickle Cell Lifespan Center, a systemwide program that provides comprehensive care for patients with sickle cell disease. The center has two dedicated clinics in Greenville and Columbia, and offers advanced services including access to disease-modifying medications, blood transfusions, transformative therapies and clinical trials for emerging treatments. The program is part of national and international sickle cell networks, allowing Prisma Health specialists to collaborate globally and bring the latest research and best practices to South Carolina patients.